The American Association of Orthodontists (AAO) during the 2025 conference in Philadelphia recognized Dr. Waheed Awotoye, an orthodontic resident at the University of Iowa, as the 2025 recipient of the prestigious Harry Sicher Research Award. This award, presented annually at the AAO Annual Session, recognizes original and impactful research conducted by graduate students in orthodontics.
Established in 1976, the Harry Sicher Research Award celebrates excellence in orthodontic research conducted during graduate education / residency. It is open to students affiliated with American Dental Association (ADA) or Canadian Dental Association (CDA)-accredited programs, and it honors studies of significant value to the art and science of orthodontics.
Dr. Awotoye’s award-winning research project leveraged whole-genome sequencing (WGS) data from 150 families in sub-Saharan Africa to uncover genetic causes of nonsyndromic cleft lip with or without cleft palate (nsCL±P)—one of the most common craniofacial anomalies worldwide. His study revealed novel pathogenic variants in genes such as AFDN, ADAM23, ITGA6, CHD7, LRP2, RYR1, SHH, and WNT3, shedding new light on the molecular mechanisms behind cleft formation. The award-winning project was mentored by Dr. Azeez Butali.
A key discovery of the study was the role of the hedgehog signaling pathway, particularly the interaction between LRP2 and SHH, which influences lipid metabolism and cleft risk. The research also highlighted incomplete penetrance, with several pathogenic variants inherited from unaffected parents, emphasizing the complexity of genetic and environmental interplay in craniofacial development.
“This award is both a tremendous honor and a powerful motivator,” says Awotoye, “It reaffirms my commitment to a career that combines scientific discovery with patient care. I hope this recognition inspires others to explore how genomics can revolutionize orthodontic treatment and improve lives.”
Dr. Awotoye also acknowledged the profound impact of his academic environment, stating, “The support system I’ve received at Iowa has been instrumental to the success of my training. From world-class mentorship and collaborative research opportunities to the unwavering support of my co-residents, faculty, and staff in the orthodontic department—as well as the warmth of the broader Iowa community—I am truly grateful for the environment that has shaped my journey.”
The recognition by the AAO Foundation not only highlights the significance of Dr. Awotoye’s research but also increases its global visibility, opening new avenues for collaboration and accelerating progress in craniofacial medicine and personalized orthodontics.
The 2025 Harry Sicher Research Award honors not just an exceptional project, but the dedication of a rising leader in the field whose work promises to reshape the future of orthodontic care.
